Data sleeping_pill;
input subject pill placebo; 
lines;
1 7.3 6.8   
2 8.5 7.9
3 6.4 6.0
4 9.0 8.4
5 6.9 6.5    
RUN;

 
proc ttest;
paired pill*placebo;
title 'paired t-test for the difference between the two population means';
run;

data compare;
set sleeping_pill;
difference=pill-placebo;
run;

proc ttest data=compare;
var difference;
title 'An alternative paired t-test: t-test on the differences';

proc univariate data=compare;
var difference;
title 'Univariate test to get signed rank test and sign test';
run;